Endofree 2.5mg Tablet 5pcs

✔️ Uses of Endofree 2.5mg Tablet

• Breast cancer
• Infertility due to anovulation

✔️ How does Endofree 2.5mg Tablet work?

Letrozole in Endofree Tablet works by reducing the level of a natural female hormone known as oestrogen that is produced in the body. Eventually, stopping the growth of the cancer cells, which depend on oestrogen for its growth.

✔️ Side Effects of Endofree 2.5mg Tablet

• Common: Hot flushes, hypercholesterolemia, fatigue, increased sweating, arthralgia, skin rash, headache, dizziness, gastrointestinal disorders, bone pain, edema, depression, weight gain, hypertension, abdominal pain, dry skin, vaginal bleeding, palpitations, joint stiffness, chest pain.
• Rare: Nervous disorders, somnolence, carpal tunnel syndrome, eye disorders, itching, vaginal discharge, weight loss, urinary tract infection, cough, increased enzymes, jaundice.

✔️ Quick Suggestions:

• You have been prescribed Letrozole for the treatment of breast cancer.
• It can be taken with or without food.
• Do not drive or do anything requiring concentration until you know how Letrozole affects you.
• It may cause increased sweating and hot flashes. Try to keep cool by wearing light and airy clothes.
• Your doctor may monitor your cholesterol level and bone mineral density (BMD) regularly as Letrozole can alter their levels.

✔️ Breast Cancer

Breast cancer is characterized by the abnormal growth of cells in the breast tissue, often influenced by estrogen. These cancerous cells can originate in different parts of the breast, including the lobules, ducts, fatty tissue, or fibrous connective tissue. As the cancer progresses, it can invade surrounding healthy breast cells and may spread to nearby lymph nodes, serving as a pathway for further metastasis to other parts of the body.

Common symptoms of breast cancer include the presence of a lump or thickening in the breast tissue, which feels distinct from the surrounding area. Other signs may include breast pain, redness, swelling, abnormal nipple discharge (such as bloody discharge), changes in the shape, size, or appearance of the breast, skin changes like peeling or scaling, and the presence of a lump or swelling under the arm.

Early detection through regular breast self-exams, clinical breast exams, and mammograms can significantly improve outcomes, as breast cancer is most treatable when diagnosed in its early stages. Prompt medical attention should be sought if any concerning symptoms are noticed, as early intervention can lead to more effective treatment and a better prognosis.

✔️ Induction of Ovulation (Female Infertility)

Induction of ovulation is a treatment approach used to help women who experience infertility due to issues with ovulation. Ovulation induction involves the use of medications to stimulate the ovaries to release eggs (ovulation) in a controlled manner, increasing the chances of conception.

This treatment is typically recommended for women who have irregular or absent ovulation, which can be caused by various factors such as polycystic ovary syndrome (PCOS), hypothalamic dysfunction, or other hormonal imbalances.

Common medications used for ovulation induction include:

• Clomiphene citrate: This medication is taken orally and works by blocking estrogen receptors in the brain, leading to increased production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate the ovaries to release eggs.
• Gonadotropins: These are injectable hormones that directly stimulate the ovaries to produce multiple follicles, each containing an egg. Gonadotropins contain either FSH alone or a combination of FSH and LH.
• Letrozole: Although primarily used to treat breast cancer, letrozole is also sometimes used off-label for ovulation induction. It works similarly to clomiphene citrate by stimulating the production of FSH and LH.

Ovulation induction is usually accompanied by careful monitoring through hormonal assays and ultrasound scans to track follicle development and determine the optimal timing for intercourse or assisted reproductive techniques such as intrauterine insemination (IUI) or in vitro fertilization (IVF).

It's essential for women undergoing ovulation induction to be monitored closely by a fertility specialist to minimize the risk of complications such as multiple pregnancies and ovarian hyperstimulation syndrome (OHSS). Additionally, lifestyle modifications such as maintaining a healthy weight, managing stress, and avoiding smoking can enhance the effectiveness of ovulation induction treatments.

✔️ Indications:

• Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.
• First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer.
• Treatment of advanced breast cancer in postmenopausal women who have previously been treated with antioestrogens.
• Pre-operative therapy in postmenopausal women with localized hormone receptor-positive breast cancer.

✔️ Pharmacology

 Letrozole inhibits estrogen biosynthesis by binding to the aromatase enzyme, reducing estrogen production in tissues. It suppresses plasma estrogen concentrations in postmenopausal patients with advanced breast cancer.

✔️ Dosage:

Recommended dose: 2.5 mg once daily for 5 years in adjuvant and extended adjuvant therapy. In metastatic disease, continue until tumor progression. No dose adjustment is needed for hepatic or renal impairment.

✔️ Administration:

• Endofree Tablet should be taken as directed by your doctor.
• Swallow it whole with a glass of water. Do not cut, break or chew the medicine.
• It can be taken with or without food.
• It would be best if you took it at a fixed time for optimal results.
• You should not consume it more than that prescribed by your doctor.

✔️ Interaction

No clinically significant interactions with cimetidine or warfarin were observed.

✔️ Contraindications

Hypersensitivity to letrozole, aromatase inhibitors, or ingredients. Contraindicated during pregnancy, lactation, and in severe hepatic dysfunction.

✔️ Pregnancy & Lactation

Not recommended during pregnancy or lactation.

✔️ Precautions & Warnings

Exercise caution in moderate hepatic dysfunction. No dose adjustment is needed for renal impairment. Patients should be aware of potential fatigue and dizziness, affecting driving or machinery operations.

✔️ Storage Conditions:

Store below 30°C, away from light and moisture. Keep out of reach of children.